Associate Professor
Marshall University School of Medicine
Huntington, West Virginia, United States
My laboratory specializes in postnatal skeletal growth. We use in vivo models to study the physiological regulation of bone elongation and the influence of environmental factors, such as temperature and diet, on the process of endochondral ossification in cartilage growth plates. I began this work as a graduate student when I designed a thesis project to measure the effects of temperature on bone length and blood flow in mice using fluorescent microspheres. With support from outstanding mentors, I extended this work during postdoctoral studies where I used multiphoton imaging to quantify molecular transport to cartilage growth plates in vivo. An anthropologist by training and anatomist by trade, I have a broad scientific background and my lab uses a variety of in vivo, ex vivo, genomic, and image-based approaches to understand how the environment impacts molecular uptake and activity in growth plates. My talk will discuss new developments in our research aimed at understanding the basis of diet-induced growth acceleration in pediatric obesity using a mouse knockout model that lacks the protease PAPP-A.
Disclosure information not submitted.
High-fat Diet Augments Linear Growth in Mice Lacking the Protease PAPP-A
Saturday, March 29, 2025
11:15 AM - 11:30 AM US PDT
